J. Hines

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

This paper introduces RIPTACs, a new class of heterobifunctional small molecules that selectively kill cancer cells by inducing protein-protein interactions that disrupt essential cellular functions.

Landscape heterogeneity and soil biota are central to multi-taxa diversity for landscape restoration

The paper tests if increasing landscape heterogeneity through tree islands enhances multi-taxa diversity in monoculture-dominated landscapes and finds that it does by fostering unique species.

Hijacking Methyl Reader proteins for Nuclear-Specific Protein Degradation

This paper designs and evaluates PROTACs that use L3MBTL3 to induce nuclear-specific degradation of FKBP12 and BRD2 by hijacking a methyl reader:E3 ligase complex.

Mutant-selective Degradation by BRAF-targeting PROTACs

This study develops BRAF-targeting PROTACs that degrade all BRAF mutants at sub-nanomolar concentrations while sparing wild-type RAF family members, showing in vivo efficacy and mechanistic insights.

A cross-scale assessment of productivity-diversity relationships

This study examines how productivity influences diversity (NPP→S) and diversity influences productivity (S→NPP) across different spatial scales in North American forests.

The geography of the Anthropocene differs between the land and the sea

The paper examines geographic differences in anthropogenic drivers of biodiversity change between land and sea, identifying distinct threat complexes with varying driver intensities.

fluxweb: a R package to easily estimate energy fluxes in food webs

fluxweb estimates energy fluxes in food webs using a steady-state model and integrates with allometric theory, providing tools for flux calculation and network stability analysis.

Biodiversity trends are stronger in marine than terrestrial assemblages

The paper analyzes biodiversity trends across 50,000 time-series, finding stronger compositional change and species turnover in marine assemblages compared to terrestrial ones.