Author

C. M. Crews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1

Frequent Co-Authors

J. Hines· 3 shared S. Jaime-Figueroa· 2 shared A. Bhardwaj· 1 shared A. Denny· 1 shared A. Hundt· 1 shared A. McGovern· 1 shared C. A. De Leon· 1 shared C. D. Forbes· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

J. Hines

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

K. Raina, C. D. Forbes, R. Stronk, J. P. Rappi, K. J. Eastman, S. W. Gerritz, X. Yu, H. Li, A. Bhardwaj, M. Forgione, A. Hundt, M. P. King, Z. M. Posner, A. Denny, A. McGovern, , C. M. Crews

This paper introduces RIPTACs, a new class of heterobifunctional small molecules that selectively kill cancer cells by inducing protein-protein interactions that disrupt essential cellular functions.

bioRxiv · Jan 1, 2023 · PreprintCancer Biology

Hijacking Methyl Reader proteins for Nuclear-Specific Protein Degradation

D. A. Nalawansha, K. Li, J. Hines, C. M. Crews

This paper designs and evaluates PROTACs that use L3MBTL3 to induce nuclear-specific degradation of FKBP12 and BRD2 by hijacking a methyl reader:E3 ligase complex.

bioRxiv · Jan 24, 2022Pharmacology & Toxicology

Targeted Degradation of Transcription Factors by TRAFTACs: Transcription Factor Targeting Chimeras

K. Samarasinghe, S. Jaime-Figueroa, K. Dai, Z. Hu, C. M. Crews

This study develops TRAFTACs, chimeric oligonucleotides that degrade transcription factors via proteasomal pathway, and demonstrates their effectiveness on NF-κB and brachyury.

bioRxiv · Oct 12, 2020Bioengineering

Mutant-selective Degradation by BRAF-targeting PROTACs

S. Alabi, S. Jaime-Figueroa, Z. Yao, Y. Gao, J. Hines, K. . T. G. Samarasinghe, L. Vogt, N. Rosen, C. M. Crews

This study develops BRAF-targeting PROTACs that degrade all BRAF mutants at sub-nanomolar concentrations while sparing wild-type RAF family members, showing in vivo efficacy and mechanistic insights.

bioRxiv · Aug 10, 2020Cancer Biology