Grandmaternal allergen exposure causes distinct epigenetic trajectories in offspring associated with airway hyperreactivity and inflammation.
K. M. Lebold, M. Cook, A. B. Pincus, K. A. Nevonen, B. A. Davis, L. Carbone, G. N. Calco, A. D. Fryer, D. B. Jacoby, M. G. Drake
This study shows grandmaternal allergen exposure creates distinct epigenetic changes in offspring that influence airway responses to allergens later in life, increasing asthma risk.
bioRxiv · Jan 25, 2022 · PreprintPhysiology