M. Cook

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 that Exhibits Antiviral Efficacy in SARS-CoV-2 Infected African Green Monkeys

Adaptor protein supersaturation drives innate immune signaling and cell fate

The paper identifies DFD adaptors as energy reservoirs through supersaturation, showing their role in innate immune signaling and cell fate decisions.

Grandmaternal allergen exposure causes distinct epigenetic trajectories in offspring associated with airway hyperreactivity and inflammation.

This study shows grandmaternal allergen exposure creates distinct epigenetic changes in offspring that influence airway responses to allergens later in life, increasing asthma risk.

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

This study identifies the structural basis of polyglutamine nucleation, showing that a four-stranded steric zipper initiates aggregation and poisons further growth.

Pro-regenerative Extracellular Matrix Hydrogel Prevents and Mitigates Pathological Alterations of Pelvic Muscles Following Birth Injury

This study shows that an extracellular matrix hydrogel prevents and reduces muscle atrophy and fibrosis in pelvic floor muscles after birth injury in rats.

Distributed brain co-processor for tracking electrophysiology and behavior during electrical brain stimulation

The paper describes a distributed brain co-processor that integrates electrophysiology and behavioral tracking during electrical brain stimulation in humans and canines.

Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior

The paper quantifies nucleation in living cells using DAmFRET and shows that kinetic barriers influence prion-like phase behavior and protein aggregation.