Early immune pressure imposed by tissue resident memory T cells sculpts tumour evolution in non-small cell lung cancer
C. E. Weeden, V. Gayevskiy, M. Trussart, C. Marceaux, N. Tubau Ribera, D. Batey, C. E. Teh, A. J. Mitchell, P. Antippa, T. Leong, D. Steinfort, L. Irving, C. L. Gordon, C. Swanton, T. P. Speed, , M.-L. Asselin-Labat
The paper shows that TRM immune pressure in ever-smokers shapes tumour evolution and immune evasion, with implications for immunotherapy.
bioRxiv · Apr 20, 2021 · PreprintCancer Biology