Author

D. H. Gray

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. E. Teh· 3 shared M. Trussart· 2 shared T. P. Speed· 2 shared A. E. Flores· 1 shared A. I. Kousa· 1 shared A. J. Mitchell· 1 shared A. L. Gomes· 1 shared A. Lazrak· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

C. E. Teh

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Early cytokine-driven adaptation of survival pathways in lymphoid cells during targeted therapies

M.-X. Luo, T. Tan, M. Trussart, A. Poch, M. H. T. Nguyen, T. P. Speed, D. G. Hicks, E. Bandala-Sanchez, H. Peng, S. Chappaz, C. Slade, D. T. Utzschneider, A. Strasser, R. Thijssen, M. E. Ritchie, , D. H. Gray

This study shows that CLL cells rapidly adapt to venetoclax by upregulating pro-survival proteins and cytokines, suggesting combination therapies targeting these pathways could improve treatment outcomes.

bioRxiv · Mar 4, 2024 · PreprintCancer Biology

Molecular control of the lymphocyte death timer

M. Ruhle, E. Thomas, E. Dann, N. Gottscheber, C. E. Teh, D. H. Gray, M. R. Dowling, S. Heinzel, P. D. Hodgkin

The paper identifies a protein-threshold mechanism that predicts lymphocyte death timing and shows how it integrates signals and is heritable across generations.

bioRxiv · Oct 25, 2023 · PreprintImmunology

Distinct subpopulations of DN1 thymocytes exhibit preferential γδ T lineage potential

S. Oh, X. Liu, S. Tomei, M. Luo, J. Skinner, S. P. Berzins, S. H. Naik, D. H. Gray, M. M. Chong

This study identifies distinct DN1 thymocyte subpopulations with preferential γδ T lineage potential using scRNA-seq in mice.

bioRxiv · Feb 25, 2022 · PreprintImmunology

Age-related epithelial defects limit thymic function and regeneration

A. I. Kousa, L. Jahn, K. Zhao, A. E. Flores, D. Granadier, K. Cooper, J. M. Sheridan, A. Lemarquis, L. Sikkema, K. V. Argyropoulos, J. Tsai, A. Lazrak, K. Nichols, N. Lee, R. Ghale, , M. R. van den Brink

The paper identifies age-related thymic epithelial cell states that impair thymic regeneration and immune function through spatial and single-cell transcriptomics.

bioRxiv · Dec 16, 2021Immunology

Early immune pressure imposed by tissue resident memory T cells sculpts tumour evolution in non-small cell lung cancer

C. E. Weeden, V. Gayevskiy, M. Trussart, C. Marceaux, N. Tubau Ribera, D. Batey, C. E. Teh, A. J. Mitchell, P. Antippa, T. Leong, D. Steinfort, L. Irving, C. L. Gordon, C. Swanton, T. P. Speed, , M.-L. Asselin-Labat

The paper shows that TRM immune pressure in ever-smokers shapes tumour evolution and immune evasion, with implications for immunotherapy.

bioRxiv · Apr 20, 2021 · PreprintCancer Biology