Author

T. P. Speed

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. E. Teh· 2 shared D. H. Gray· 2 shared M. Trussart· 2 shared A. J. Mitchell· 1 shared A. Kallies· 1 shared A. Pfefferle· 1 shared A. Poch· 1 shared A. Strasser· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

C. E. Teh

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3 papers

Recent·Most cited

Early cytokine-driven adaptation of survival pathways in lymphoid cells during targeted therapies

M.-X. Luo, T. Tan, M. Trussart, A. Poch, M. H. T. Nguyen, T. P. Speed, D. G. Hicks, E. Bandala-Sanchez, H. Peng, S. Chappaz, C. Slade, D. T. Utzschneider, A. Strasser, R. Thijssen, M. E. Ritchie, , D. H. Gray

This study shows that CLL cells rapidly adapt to venetoclax by upregulating pro-survival proteins and cytokines, suggesting combination therapies targeting these pathways could improve treatment outcomes.

bioRxiv · Mar 4, 2024 · PreprintCancer Biology

Early immune pressure imposed by tissue resident memory T cells sculpts tumour evolution in non-small cell lung cancer

C. E. Weeden, V. Gayevskiy, M. Trussart, C. Marceaux, N. Tubau Ribera, D. Batey, C. E. Teh, A. J. Mitchell, P. Antippa, T. Leong, D. Steinfort, L. Irving, C. L. Gordon, C. Swanton, T. P. Speed, , M.-L. Asselin-Labat

The paper shows that TRM immune pressure in ever-smokers shapes tumour evolution and immune evasion, with implications for immunotherapy.

bioRxiv · Apr 20, 2021 · PreprintCancer Biology

The ratio of exhausted to resident infiltrating lymphocytes is prognostic for colorectal cancer patient outcome

M. Foroutan, R. Molania, A. Pfefferle, C. Behrenbruch, A. Kallies, T. P. Speed, J. Cursons, N. D. Huntington

This study identifies signatures of lymphocyte residency and exhaustion in colorectal cancer using single-cell RNA-seq and shows their association with patient survival outcomes.

bioRxiv · Dec 19, 2020Cancer Biology