Author

D. Bickel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Ecology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

H. Gohlke· 3 shared M. Etzkorn· 2 shared M. Gopalswamy· 2 shared S. Schott-Verdugo· 2 shared A. Backstrom· 1 shared A. K. Hahs· 1 shared A. Moran-Ordonez· 1 shared A. N. Andersen· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPharmacology & Toxicology

H. Gohlke

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO and exhibiting an improved, selective antiproliferative effect in RUNX-ETO positive cells

M. Gopalswamy, D. Bickel, N. Dienstbier, J.-W. Tu, S. Schott-Verdugo, S. Bhatia, M. Etzkorn, H. Gohlke

The paper identifies non-charged analogs of the inhibitor 7.44 that show improved antiproliferative effects against RUNX1-ETO positive cells.

bioRxiv · Jun 11, 2024 · PreprintPharmacology & Toxicology

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

M. Gopalswamy, T. Kroeger, D. Bickel, B. Frieg, S. Akter, S. Schott-Verdugo, A. Viegas, T. Pauly, M. Mayer, J. Przibilla, J. Reiners, L. Nagel-Steger, S. H. J. Smits, G. Groth, M. Etzkorn, H. Gohlke

This paper characterizes a small-molecule inhibitor of RUNX1/ETO tetramerization, showing it disrupts tetramer stability and has favorable pharmacokinetic properties for potential anti-leukemic therapy.

bioRxiv · Dec 22, 2021Biophysics

Respiratory and C4-photosynthetic NAD-malic enzyme coexist in bundle sheath cells mitochondria and evolved via association of differentially adapted subunits

M. Huedig, M. A. Tronconi, J. P. Zubimendi, T. L. Sage, G. Poschmann, D. Bickel, H. Gohlke, V. G. Maurino

The paper shows that in C4 Cleome species, NAD-ME functions as both a decarboxylase and housekeeping enzyme through differentially adapted beta subunits in mitochondria.

bioRxiv · Jun 16, 2021Plant Biology

Indigenous plants promote insect biodiversity in urban greenspaces

L. Mata, A. N. Andersen, A. Moran-Ordonez, A. K. Hahs, A. Backstrom, C. D. Ives, D. Bickel, D. Duncan, E. Palma, F. Thomas, K. Cranney, K. Walker, I. Shears, L. Semeraro, M. Malipatil, , Y. Lynch

This study shows that indigenous plants, especially graminoids, support higher insect biodiversity in urban greenspaces compared to nonnative species.

bioRxiv · May 29, 2020Ecology