Author

S. Schott-Verdugo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Approach:biophysical modeling· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

H. Gohlke· 6 shared G. Groth· 2 shared J. Reiners· 2 shared A. Hoeppner· 1 shared A. Kedrov· 1 shared A. Viegas· 1 shared B. Frieg· 1 shared B. Thiele· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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6 shared papersBiophysics

H. Gohlke

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6 papers

Recent·Most cited

Molecular Mechanisms Underlying Medium-Chain Free Fatty Acid-regulated Activity of the Phospholipase PlaF from P. aeruginosa

R. Gentile, M. Modric, B. Thiele, K.-E. Jaeger, F. Kovacic, S. Schott-Verdugo, H. Gohlke

This study investigates how medium-chain free fatty acids regulate PlaF activity through molecular dynamics simulations and free energy computations, revealing mechanisms of dimerization and activation.

bioRxiv · May 2, 2023 · PreprintBiophysics

Spectroscopic and QM/MM studies of the Cu(I) binding site of the plant ethylene receptor ETR1

G. Cutsail, S. Schott-Verdugo, L. Müller, S. DeBeer, G. Groth, H. Gohlke

The paper characterizes the Cu(I) binding site of the plant ethylene receptor ETR1 using spectroscopy and QM/MM simulations, showing ethylene-induced coordination changes.

bioRxiv · Jun 13, 2022Biophysics

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

M. Gopalswamy, T. Kroeger, D. Bickel, B. Frieg, S. Akter, S. Schott-Verdugo, A. Viegas, T. Pauly, M. Mayer, J. Przibilla, J. Reiners, L. Nagel-Steger, S. H. J. Smits, G. Groth, M. Etzkorn, H. Gohlke

This paper characterizes a small-molecule inhibitor of RUNX1/ETO tetramerization, showing it disrupts tetramer stability and has favorable pharmacokinetic properties for potential anti-leukemic therapy.

bioRxiv · Dec 22, 2021Biophysics

A MademoiseLLE domain binding platform links the key RNA transporter to endosomes

S.-K. Devan, S. Schott-Verdugo, K. Muentjes, L. Bismar, J. Reiners, E. Hachani, L. Schmitt, A. Hoeppner, S. H. Smits, H. Gohlke, M. Feldbruegge

The paper identifies MLLE domains in Rrm4 as essential for endosomal attachment, revealing a hierarchical binding platform for mRNA transport.

bioRxiv · Oct 25, 2021Microbiology

Unsaturated fatty acids augment protein transport via the SecA:SecYEG translocon

M. Kamel, M. Löwe, S. Schott-Verdugo, H. Gohlke, A. Kedrov

This study shows that unsaturated fatty acids enhance SecA:SecYEG-mediated protein transport by altering the membrane interface and promoting SecA binding.

bioRxiv · Mar 26, 2021Biophysics

The puzzle of metabolite exchange and identification of putative octotrico peptide repeat expression regulators in the nascent photosynthetic organelles of Paulinella chromatophora

L. Oberleitner, G. Poschmann, L. Macorano, S. Schott-Verdugo, H. Gohlke, K. Stühler, E. C. M. Nowack

This paper identifies novel chromatophore-targeted proteins in Paulinella chromatophora that may regulate gene expression and membrane permeability, revealing unique mechanisms of nuclear control over the organelle.

bioRxiv · Aug 26, 2020Evolutionary Biology