Author

S. H. J. Smits

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

H. Gohlke· 3 shared A. Harris· 1 shared A. Viegas· 1 shared B. F. Luisi· 1 shared B. Frieg· 1 shared C. Pfleger· 1 shared D. Bickel· 1 shared D. Danso· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

H. Gohlke

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivOct 14, 2022

The first archaeal PET-degrading enzyme belongs to the feruloyl-esterase family

P. Perez-Garcia, J. Chow, E. Costanzi…·W. R. Streit

The paper identifies and characterizes PET46, an archaeal feruloyl esterase capable of degrading PET, expanding the known diversity of PET-hydrolyzing enzymes.

DOI 10.1038/s42004-023-00998-z

proteomicsexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivDec 22, 2021

Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

M. Gopalswamy, T. Kroeger, D. Bickel…·H. Gohlke

This paper characterizes a small-molecule inhibitor of RUNX1/ETO tetramerization, showing it disrupts tetramer stability and has favorable pharmacokinetic properties for potential anti-leukemic therapy.

DOI 10.1038/s41598-022-17913-6

humanbiophysical modeling

𝕏 PostBluesky

MicrobiologybioRxivFeb 9, 2021

Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

A. Harris, M. Wagner, D. Du…·L. Schmitt

This study reveals the structural and functional mechanism of the yeast Pdr5 transporter, showing how it uses ATP to drive drug efflux through a conformational cycle and an amphipathic channel.

DOI 10.1038/s41467-021-25574-8

yeastexperimental assay

𝕏 PostBluesky