G. Poschmann

Integrative modeling of guanylate binding protein dimers

The paper models dimer structures of GBP proteins using integrative methods, revealing structural differences that explain functional divergence.

Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell

The paper shows that MbxA from Moraxella bovis, secreted via an E. coli system, induces membrane blebbing and cell death in human cells.

Redox regulation of the SARS-CoV-2 main protease provides new opportunities for drug design

This study identifies redox regulation of SARS-CoV-2 Mpro and discovers antiviral reagents that mimic redox switching, suggesting new drug targets.

GBP2 engages Galectin-9 for immunity against Toxoplasma gondii

This study identifies Galectin-9 as a critical interaction partner of mGBP2 required for immune control of Toxoplasma gondii.

Evolution of a putative, host-derived endosymbiont division ring and symbiosis-induced proteome rearrangements in the trypanosomatid Angomonas deanei

This study identifies nucleus-encoded proteins targeting the endosymbiont in Angomonas deanei and reveals a division ring structure similar to mitochondrial and plastid division machineries.

Respiratory and C4-photosynthetic NAD-malic enzyme coexist in bundle sheath cells mitochondria and evolved via association of differentially adapted subunits

The paper shows that in C4 Cleome species, NAD-ME functions as both a decarboxylase and housekeeping enzyme through differentially adapted beta subunits in mitochondria.

The puzzle of metabolite exchange and identification of putative octotrico peptide repeat expression regulators in the nascent photosynthetic organelles of Paulinella chromatophora

This paper identifies novel chromatophore-targeted proteins in Paulinella chromatophora that may regulate gene expression and membrane permeability, revealing unique mechanisms of nuclear control over the organelle.

FeS-cluster coordination of vertebrate thioredoxin regulates suppression of hypoxia-induced factor 2α through iron regulatory protein 1

The paper shows FeS-cluster coordination of Trx1 regulates hypoxia-induced factor 2α suppression via IRP1 by linking redox and iron homeostasis.

Quantitative insights into the cyanobacterial cell economy

The paper quantifies cyanobacterial physiological responses to varying light conditions and identifies proteome allocation changes with growth rate.