Intrinsic Gating Behavior of Voltage-Gated Sodium Channels Predetermines Regulation by Auxiliary β-subunits
N. Brake, A. S. Mancino, Y. Yan, T. Shimomura, H. Silveira, Y. Kubo, A. Khadra, D. Bowie
This study shows that the intrinsic movement order of voltage-sensing domains in Nav channels determines their susceptibility to regulation by β1 and β3 subunits, explaining variable regulatory effects across channel isoforms.
bioRxiv · Feb 25, 2021 · PreprintBiophysics