Author

A. S. Mancino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Organism:human· 1

Frequent Co-Authors

A. Frost· 1 shared A. Khadra· 1 shared D. Bowie· 1 shared D. Julius· 1 shared F. R. Moss· 1 shared H. Silveira· 1 shared N. Brake· 1 shared T. Shimomura· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. Frost

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2 papers

Recent·Most cited

Structural basis of TRPV1 modulation by endogenous bioactive lipids

W. R. Arnold, A. S. Mancino, F. R. Moss, A. Frost, D. Julius, Y. Cheng

This study identifies a lipid-binding pocket in TRPV1 and shows that its occupancy by phosphoinositides modulates channel activity, with lipid ejection triggering activation.

bioRxiv · May 11, 2023Biochemistry

Intrinsic Gating Behavior of Voltage-Gated Sodium Channels Predetermines Regulation by Auxiliary β-subunits

N. Brake, A. S. Mancino, Y. Yan, T. Shimomura, H. Silveira, Y. Kubo, A. Khadra, D. Bowie

This study shows that the intrinsic movement order of voltage-sensing domains in Nav channels determines their susceptibility to regulation by β1 and β3 subunits, explaining variable regulatory effects across channel isoforms.

bioRxiv · Feb 25, 2021 · PreprintBiophysics