Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling
N. D. Carrillo, M. Chen, T. Wen, P. Awasthi, C. Sterling, D. Brahmbhatt, V. L. Cryns, R. A. Anderson
The paper identifies PITP/β and PI4KIIα as key regulators initiating nuclear p53-PIPn signaling through PI transfer and phosphorylation, with implications for cancer therapy.
bioRxiv · May 8, 2023Cell Biology