T. Wen

Regulation of the poly(A) Polymerase Star-PAP by a Nuclear Phosphoinositide Signalosome

This study shows that Star-PAP is regulated by phosphoinositides in response to stress through interactions with PITP/{beta}, PI kinases/phosphatases, and HSP27.

Regulation of NRF2 by Phosphoinositides and Small Heat Shock Proteins

This study shows that PIPKIγ and HSP27 regulate NRF2 stability and function, promoting stress resistance and suggesting them as potential drug targets in cancer.

Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling

The paper identifies PITP/β and PI4KIIα as key regulators initiating nuclear p53-PIPn signaling through PI transfer and phosphorylation, with implications for cancer therapy.

VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8+ T cell killing in colorectal cancer

This study identifies VPS9D1-AS1 as a lncRNA that enhances TGF-β signaling and immune evasion in colorectal cancer by modulating translation and ISG expression.

Pancreatic Tumor Eradication via Selective PIN1 Inhibition in Cancer Associated Fibroblasts and T Lymphocytes Engagement

This study demonstrates that selective PIN1 inhibition in CAFs and engagement of T lymphocytes using a bispecific system effectively eradicates pancreatic tumors in mice.

Targeting of Cdc42 GTPase in regulatory T cells unleashes anti-tumor T cell immunity

This study shows that targeting Cdc42 in regulatory T cells promotes anti-tumor immunity without causing autoimmunity by inducing Treg plasticity and altering pH through carbonic anhydrase I.

A p53-Phosphoinositide Signalosome Regulates Nuclear Akt Activation

The paper shows p53 forms a nuclear PI3K-Akt pathway that activates Akt independently of the canonical membrane pathway, with implications for cancer therapy.

Cryo-EM structure of the human TACAN channel in a closed state

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

Dynamic assembly of the calcium hemostasis modulator 1 channel gates ATP permeation

This study reports cryo-EM structures of CALHM1 channels and proposes a mechanism for ATP permeation through dynamic N-helix movement.