In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming
A. V. Antunes, M. Shahinas, C. Swale, D. C. Farhat, C. Ramakrishnan, C. Bruley, D. Cannella, C. Corrao, Y. Coute, A. B. Hehl, A. Bougdour, I. Coppens, M.-a. Hakimi
This study shows that AP2XII-1 and AP2XI-2 transcription factors reprogram Toxoplasma gondii tachyzoites to merozoites in vitro, enabling the production of pre-sexual stages without using cats.
bioRxiv · Jan 16, 2023 · PreprintMicrobiology