Author

M. W. Bowler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:protein structure· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

A. BOUGDOUR· 2 shared C. MAS· 2 shared C. SWALE· 2 shared E. Pellegrini· 2 shared F. G. Kozielski· 2 shared J. von Velsen· 2 shared L. Belmudes· 2 shared M.-a. HAKIMI· 2 shared

Activity by Year

2016-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

A. BOUGDOUR

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Author profile →

9 papers

Recent·Most cited

The MAP2Ks can use ADP to phosphorylate and activate their substrate MAPKs in vitro

P. Juyoux, J. von Velsen, E. Pellegrini, M. W. Bowler

The paper shows that MAP2Ks can phosphorylate and activate MAPKs using ADP in vitro, suggesting a potential role in maintaining signaling under ATP-depleted conditions.

bioRxiv · Feb 22, 2024Biochemistry

High-confidence placement of difficult-to-fit fragments into electron density by using anomalous signals - a case study using hits targeting SARS-CoV-2 non-structural protein 1

F. G. Kozielski, S. Ma, M. W. Bowler, V. Mykhaylyk, N. Pinotsis

This paper demonstrates a method to identify multiple binding orientations of small molecule fragments using anomalous signals from sulphur and chlorine atoms, applied to SARS-CoV-2 nsp1 fragments.

bioRxiv · Jun 16, 2023 · PreprintBiochemistry

Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

P. Juyoux, I. Galdadas, D. Gobbo, J. von Velsen, M. Pelosse, M. Tully, O. Vadas, F. L. Gervasio, E. Pellegrini, M. W. Bowler

The paper determines the structure and activation mechanism of the MKK6-p38α complex using cryo-EM and MD simulations, revealing how phosphorylation and interactions drive MAPK specificity.

bioRxiv · Jul 4, 2022Biophysics

Two ligand-binding sites on SARS-CoV-2 non-structural protein 1 revealed by fragment-based x-ray screening

S. Ma, S. Damfo, J. Lou, N. Pinotsis, M. W. Bowler, S. Haider, F. G. Kozielski

This study identifies two ligand-binding sites on SARS-CoV-2 nsp1 using X-ray crystallography and fragment-based screening, offering a foundation for inhibitor development.

bioRxiv · Jun 12, 2022Biochemistry

A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria

C. SWALE, V. BELLINI, M. W. Bowler, F. NARDELLA, M.-P. Brenier-Pinchart, D. Cannella, L. Belmudes, C. MAS, Y. Coute, F. LAURENT, A. Scherf, A. BOUGDOUR, M.-a. HAKIMI

This paper identifies altiratinib as a selective inhibitor of PRP4K/CLK3 kinases in apicomplexan parasites, showing broad-spectrum antiparasitic activity against toxoplasmosis and malaria.

bioRxiv · Nov 3, 2021 · PreprintMicrobiology

A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental genes partitioning in Toxoplasma

D. C. Farhat, M. W. Bowler, G. Communie, D. PONTIER, L. Belmudes, C. MAS, C. Corrao, Y. COUTE, A. BOUGDOUR, T. LAGRANGE, M.-a. HAKIMI, C. Swale

This paper identifies an m6A-dependent polyadenylation mechanism in Toxoplasma gondii that prevents transcriptional read-through and maintains transcriptome integrity, similar to a plant mechanism.

bioRxiv · Feb 23, 2021Microbiology

Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence

G. Bullen, J. D. Galson, P. Villar, L. Moreels, L. Ledsgaard, G. Mattiuzzo, G. Hall, E. M. Bentley, E. W. Masters, D. Tang, S. Millett, D. Tongue, R. Brown, I. Diamantopoulos, K. Parthiban, , A. Karatt-Vellatt

The paper identifies potent neutralising antibodies from early COVID-19 patient samples and shows high convergence in antibody sequences across studies.

bioRxiv · Dec 29, 2020 · PreprintImmunology

A comparative anatomy of protein crystals: lessons from the automatic processing of 56,000 samples

O. Svensson, M. Gilski, D. Nurizzo, M. W. Bowler

The paper analyzes data from 56,000 protein crystals processed by MASSIF-1 to evaluate theoretical assumptions about crystal properties and their relationship to diffraction and molecular characteristics.

bioRxiv · Mar 4, 2019Biophysics

Raoult’s law revisited: accurately predicting equilibrium relative humidity points for humidity control experiments

M. G. Bowler, D. R. Bowler, M. W. Bowler

The paper measures equilibrium relative humidity for common precipitants and shows agreement with Raoult’s law using improved humidity control.

bioRxiv · Nov 22, 2016Biophysics