Author

D. C. Jeffares

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:DNA methylation· 1 Research Focus:fine-mapping· 1 Research Focus:GWAS / association mapping· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

C. A. Grace· 3 shared D. L. Costa· 2 shared J. L. Reis-Cunha· 2 shared S. Forrester· 2 shared A. Aare· 1 shared C. C. H. N. Costa· 1 shared C. d. M. Pedrozo e Silva de Azevedo· 1 shared C. H. N. Costa· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersEvolutionary Biology

C. A. Grace

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Author profile →

3 papers

Recent·Most cited

Strong effects of parasite genotype on drug susceptibility in the Indian subcontinent

C. A. Grace, J. L. Reis-Cunha, D. C. Jeffares

The paper assesses the contribution of parasite genotype to drug resistance in Leishmania donovani using heritability and GWAS analyses, finding SNP/indel associations with SSG resistance and copy number variants with MIL resistance.

bioRxiv · Aug 17, 2022 · PreprintEvolutionary Biology

Parasite genotype is a major predictor of mortality from visceral leishmaniasis

C. A. Grace, K. S. Sousa Carvalho, M. I. Sousa Lima, V. Costa Silva, J. L. Reis-Cunha, M. J. Brune, S. Forrester, C. d. M. Pedrozo e Silva de Azevedo, D. L. Costa, D. Speed, J. Mottram, D. C. Jeffares, C. H. N. Costa

This study identifies parasite genotype as a major predictor of mortality from visceral leishmaniasis in Brazil, with heritability estimates up to 83% for mortality.

bioRxiv · Jul 28, 2022Evolutionary Biology

Multiple targets of balancing selection in Leishmania donovani complex parasites

C. A. Grace, S. Forrester, V. C. Silva, A. Aare, H. Kilford, Y. P. Chew, S. James, D. L. Costa, J. C. Mottram, C. C. H. N. Costa, D. C. Jeffares

This study identifies five genetically distinct populations in Leishmania donovani complex parasites and finds balancing selection signals not shared between populations, highlighting 19 candidate genes.

bioRxiv · Mar 2, 2021 · PreprintEvolutionary Biology