Author

J. Mottram

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

S. Forrester· 2 shared A. L. Goundry· 1 shared A. P. C. A. Lima· 1 shared B. T. Dias· 1 shared C. A. Grace· 1 shared C. d. M. Pedrozo e Silva de Azevedo· 1 shared C. H. N. Costa· 1 shared D. C. Jeffares· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersEvolutionary Biology

S. Forrester

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2 papers

Recent·Most cited

Parasite genotype is a major predictor of mortality from visceral leishmaniasis

C. A. Grace, K. S. Sousa Carvalho, M. I. Sousa Lima, V. Costa Silva, J. L. Reis-Cunha, M. J. Brune, S. Forrester, C. d. M. Pedrozo e Silva de Azevedo, D. L. Costa, D. Speed, J. Mottram, D. C. Jeffares, C. H. N. Costa

This study identifies parasite genotype as a major predictor of mortality from visceral leishmaniasis in Brazil, with heritability estimates up to 83% for mortality.

bioRxiv · Jul 28, 2022Evolutionary Biology

Tissue specific dual RNA-seq defines host-parasite interplay in murine visceral leishmaniasis caused by Leishmania donovani and Leishmania infantum

S. Forrester, A. L. Goundry, B. T. Dias, T. Leal-Calvo, M. Moraes, P. Kaye, J. Mottram, A. P. C. A. Lima

This study uses dual RNA-seq to compare host and parasite gene expression in mouse models of Leishmania donovani and Leishmania infantum infections, identifying common and species-specific transcriptional responses.

bioRxiv · Feb 4, 2022Microbiology