Author

J. C. Mottram

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 3 Biochemistry· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

V. Geoghegan· 4 shared E. Brown· 3 shared K. Newling· 3 shared N. G. Jones· 3 shared A. J. Wilkinson· 2 shared C. M. C. Catta-Preta· 2 shared E. Myburgh· 2 shared E. V. C. Alves-Ferreira· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

V. Geoghegan

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Author profile →

10 papers

Recent·Most cited

Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery

C. N. Russell, J. L. Carter, J. M. Borgia, J. Bush, F. Calderon, R. Gabarro, S. J. Conway, J. C. Mottram, A. J. Wilkinson, N. G. Jones

This paper identifies LdBDF5 as a potential drug target for antileishmanial therapy by showing its interaction with human bromodomain inhibitors and demonstrating antipromastigote activity of SGC-CBP30.

bioRxiv · Aug 21, 2023Biochemistry

TORC1 is an essential regulator of nutrient-dependent differentiation in Leishmania

E. Myburgh, V. Geoghegan, E. V. C. Alves-Ferreira, Y. R. Nievas, J. S. Grewal, E. Brown, K. McLuskey, J. C. Mottram

This study identifies TORC1 as essential for nutrient-dependent differentiation in Leishmania, showing its role in both promastigote and amastigote stages.

bioRxiv · Oct 20, 2022 · PreprintCell Biology

Bromodomain factor 5 is an essential transcriptional regulator of the Leishmania genome.

N. G. Jones, V. Geoghegan, G. Moore, J. B. T. Carnielli, K. Newling, F. Calderon, R. Gabarro, J. Martin, R. Prinjha, I. Rioja, A. J. Wilkinson, J. C. Mottram

This study identifies BDF5 as essential for Leishmania gene expression and survival by analyzing its role in chromatin interpretation and transcriptional regulation.

bioRxiv · Sep 29, 2021Cell Biology

Widespread roles of Trypanosoma brucei ATR in nuclear genome function and transmission are linked to R-loops

J. A. Black, K. Crouch, E. M. Briggs, L. Lemgruber, C. Lapsley, L. R. O. Tosi, J. C. Mottram, R. McCulloch

This study shows that ATR in Trypanosoma brucei is involved in genome maintenance, R-loop regulation, and chromosome segregation, despite DNA damage and continued cell division after ATR depletion.

bioRxiv · Sep 9, 2021 · PreprintCell Biology

Protein kinase signalling at the Leishmania kinetochore captured by XL-BioID

V. Geoghegan, N. G. Jones, A. Dowle, J. C. Mottram

The paper develops XL-BioID to study kinase signaling at the Leishmania kinetochore, identifying a novel protein and characterizing phosphosites during the cell cycle.

bioRxiv · Jul 8, 2021 · PreprintBiochemistry

Multiple targets of balancing selection in Leishmania donovani complex parasites

C. A. Grace, S. Forrester, V. C. Silva, A. Aare, H. Kilford, Y. P. Chew, S. James, D. L. Costa, J. C. Mottram, C. C. H. N. Costa, D. C. Jeffares

This study identifies five genetically distinct populations in Leishmania donovani complex parasites and finds balancing selection signals not shared between populations, highlighting 19 candidate genes.

bioRxiv · Mar 2, 2021 · PreprintEvolutionary Biology

Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival

N. Baker, C. M. C. Catta-Preta, R. Neish, J. Sadlova, B. Powell, E. V. C. Alves-Ferreira, V. Geohegan, J. B. T. Carnielli, K. Newling, C. Hughes, B. Vojtkova, J. Anand, A. Mihut, P. Walrad, L. G. Wilson, , J. C. Mottram

The paper systematically analyzes Leishmania protein kinases to identify those regulating differentiation and survival across life cycle stages.

bioRxiv · Sep 6, 2020Microbiology

Essential roles for deubiquitination in Leishmania life cycle progression

A. Damianou, R. J. Burge, C. Catta-Preta, V. Geoghegan, Y. R. Nievas, K. Newling, E. Brown, R. Burchmore, B. Rodenko, J. C. Mottram

This study identifies essential deubiquitinating enzymes (DUBs) in Leishmania life cycle progression and demonstrates their critical role in differentiation and intracellular survival.

PLOS Pathogens · Jun 16, 2020Peer-reviewedMicrobiology

Role for the flagellum attachment zone in the resolution of cell membrane morphogenesis during Leishmania cell division

J. Sunter, C. Halliday, R. Yanase, C. M. C. Catta-Preta, F. Moreira-Leite, J. Myskova, K. Pruzinova, P. Volf, J. C. Mottram

This study investigates the role of FAZ2 in Leishmania cell division, showing that its loss disrupts membrane organization and reduces parasite viability in sand flies and mice.

bioRxiv · Mar 26, 2020Cell Biology

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

M. Saldivia, S. P. S. Rao, E. Fang, E. Myburgh, E. Brown, A. J. M. Wollman, R. Ritchie, S. B. Lakhsminarayana, Y. L. Chen, D. Patra, H. X. Koh, S. Williams, F. Supek, D. Paape, C. Bower-Lepts, , J. C. Mottram

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.

bioRxiv · Apr 24, 2019Microbiology