PhysiologybioRxivPreprint
Absence of the bile acid enzyme CYP8B1 increases brain chenodeoxycholic acid and reduces neuronal excitotoxicity in mice
V. F. Monteiro-Cardoso, X. Y. Yeo, H.-G. Bae…·R. R. Singaraja
This study shows that absence of CYP8B1 increases brain chenodeoxycholic acid (CDCA) levels, reducing neuronal excitotoxicity and stroke infarct area in mice.
DOI 10.1101/2022.12.11.520005