DNAJB12 and Hsp70 Facilitate the Conformation Specific Degradation of Arrested N1303K-CFTR Intermediates by ERQC-Autophagy
L. He, A. S. Kennedy, S. Houck, A. A. Aleksandrov, N. L. Quinney, M. Gentzsch, D. Cholon, S. H. Randell, H. Y. Ren, D. M. Cyr
This study shows DNAJB12 and Hsp70 facilitate conformation-specific degradation of N1303K-CFTR intermediates via ERQC-autophagy, distinct from ERAD.
bioRxiv · Oct 28, 2020 · PreprintCell Biology