Author

A. S. Kennedy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:imaging· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2

Frequent Co-Authors

B. P. Riesenberg· 2 shared D. M. Cyr· 2 shared E. G. Hunt· 2 shared E. J. Gandy· 2 shared H. Y. Ren· 2 shared J. E. Thaxton· 2 shared K. E. Hurst· 2 shared P. Gao· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

B. P. Riesenberg

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Effects of satellite-linked telemetry tags on humpback whales in the Gulf of Maine: photographic assessment of tag sites

F. M. D. Gulland, J. Robbins, A. N. Zerbini, V. Andrews-Goff, M. Berube, P. J. Clapham, M. Double, N. Gales, A. S. Kennedy, S. Landry, D. K. Mattila, D. Sandilands, J. E. Tackaberry, M. M. Uhart, R. E. T. Vanstreels

This study assesses the effects of satellite-linked telemetry tags on humpback whales, finding that integrated tags caused less severe tissue damage than non-integrated ones.

bioRxiv · Feb 7, 2024Ecology

Acetyl-CoA Carboxylase Obstructs CD8+ T-Cell Lipid Utilization and Energy Synthesis in the Tumor Microenvironment

E. G. Hunt, K. E. Hurst, B. P. Riesenberg, A. S. Kennedy, E. J. Gandy, A. M. Andrews, E. D. Wallace, P. Gao, M. Coleman, J. E. Thaxton

This study shows that acetyl-CoA carboxylase (ACC) activity in T cells within the tumor microenvironment inhibits lipid utilization and energy synthesis, and its restriction enhances T cell survival and antitumor function.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control

B. P. Riesenberg, E. J. Gandy, A. S. Kennedy, E. G. Hunt, K. E. Hurst, E. L. Sedlacek, P. Gao, M. J. Emanuele, J. Modliszewski, J. M. Green, J. J. Milner, L. Wiseman, J. E. Thaxton

This study shows that enhancing the adaptive IRE1 UPR pathway in T cells improves tumor control by reducing mitochondrial toxicity and chronic ER stress.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Lysosomes dock to omegasomes and ER-connected Phagophores During DNAJB12 and GABARAP-Dependent Selective-Autophagy of Misfolded P23H-Rhodopsin

A. S. Kennedy, H. Y. Ren, V. Madden, D. M. Cyr

The paper identifies lysosome docking to omegasomes as a critical step in DNAJB12 and GABARAP-dependent autophagy of misfolded P23H-Rhodopsin.

bioRxiv · Oct 20, 2021 · PreprintCell Biology

DNAJB12 and Hsp70 Facilitate the Conformation Specific Degradation of Arrested N1303K-CFTR Intermediates by ERQC-Autophagy

L. He, A. S. Kennedy, S. Houck, A. A. Aleksandrov, N. L. Quinney, M. Gentzsch, D. Cholon, S. H. Randell, H. Y. Ren, D. M. Cyr

This study shows DNAJB12 and Hsp70 facilitate conformation-specific degradation of N1303K-CFTR intermediates via ERQC-autophagy, distinct from ERAD.

bioRxiv · Oct 28, 2020 · PreprintCell Biology