S. Uphoff

Regulatory fine-tuning and horizontal gene transfer stabilize mobile colistin resistance

This study shows how regulatory evolution and horizontal gene transfer stabilize mcr-1 resistance in E. coli despite fitness costs.

Environmental feedback drives oxidative stress response heterogeneity in bacterial populations

The paper shows that bacterial oxidative stress response heterogeneity arises from deterministic environmental feedback rather than stochastic noise, improving population-level stress tolerance.

Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress

The paper shows that adaptation delays in bacteria cause mutation bursts during oxidative stress, which can be mitigated by prior stress exposure or constitutive OxyR activation.

Cellular heterogeneity in DNA alkylation repair as a trade-off between cell survival and genetic plasticity

The paper shows that DNA repair in E. coli creates cellular heterogeneity, balancing survival and mutability to enhance population evolvability.

Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins

This study shows that bacterial DNA-binding proteins spend most of their search time bound to DNA, with frequent short-lived interactions slowing their movement through the nucleoid.

Non-random segregation of sister chromosomes by Escherichia coli MukBEF axial cores

This study shows how Escherichia coli MukBEF axial cores direct chromosome segregation and non-random inheritance through interactions with MatP and DNA replication dynamics.

Gene expression noise randomizes the adaptive response to DNA alkylation damage in E. coli

This study models how gene expression noise affects the adaptive response to DNA alkylation damage in E. coli, showing that low Ada molecule counts lead to stochastic delays and reduced response strength with higher growth rates.

Choosing the right label for single-molecule tracking in live bacteria: Side-by-side comparison of photoactivatable fluorescent protein and Halo tag dyes

The paper compares photoactivatable fluorescent proteins and Halo tag dyes for single-molecule tracking in live bacteria, evaluating their performance in terms of brightness, photostability, and tracking accuracy.

Scc2/Nipbl Hops Between Chromosomal Cohesin Rings After Loading

This study shows Scc2/Nipbl dynamically hops between chromosomal cohesin rings after loading, suggesting a post-loading function in DNA loop extrusion.