Targeting Cblb-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cells responses
G. Monticone, F. Csibi, S. Leit, D. Ciccone, A. Champhekar, J. E. Austin, D. A. Ucar, F. Hossain, Z. Huang, S. V. Ibba, A. H. Boulares, N. Carpino, S. Majumder, K. Xu, B. A. Osborne, , L. Miele
This study identifies a novel immunosuppressive pathway involving Cbl-b-mediated Notch1 degradation and shows that targeting this axis enhances CD8+ T-cell responses and anti-cancer immunity.
bioRxiv · Mar 15, 2022Cancer Biology