Author

G. Monticone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

F. Hossain· 2 shared L. Miele· 2 shared S. Majumder· 2 shared A. Champhekar· 1 shared A. H. Boulares· 1 shared B. A. Osborne· 1 shared C. Loh· 1 shared C. Urech· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

F. Hossain

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2 papers

Recent·Most cited

The efficacy of CB-103, a first-in-class transcriptional Notch inhibitor, in preclinical models of breast cancer

M. Vigolo, C. Urech, S. Lamy, G. Monticone, J. Zabaleta, F. Hossain, D. Wyczechowska, L. Del Valle, R. O'Regan, L. Miele, R. Lehal, S. Majumder

This paper evaluates the efficacy and safety of CB-103, a Notch inhibitor, in preclinical breast cancer models, showing synergistic effects with existing therapies.

bioRxiv · Jul 6, 2023Cancer Biology

Targeting Cblb-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cells responses

G. Monticone, F. Csibi, S. Leit, D. Ciccone, A. Champhekar, J. E. Austin, D. A. Ucar, F. Hossain, Z. Huang, S. V. Ibba, A. H. Boulares, N. Carpino, S. Majumder, K. Xu, B. A. Osborne, , L. Miele

This study identifies a novel immunosuppressive pathway involving Cbl-b-mediated Notch1 degradation and shows that targeting this axis enhances CD8+ T-cell responses and anti-cancer immunity.

bioRxiv · Mar 15, 2022Cancer Biology