Z. Huang

Marker-specific pixel attribution for single-cell protein quantification with PixAQ

PixAQ improves single-cell protein quantification in imaging mass cytometry by assigning pixel signals to specific markers using spatial and intensity models.

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

This study shows that HSCs produce BMP9/10, which regulate KCs and ECs to maintain liver homeostasis, and their deletion leads to fibrosis and iron overload.

Nicotine Ameliorates α-synuclein Pre-formed Fibril-Induced Behavioral Deficits and Pathological Features in Mice

This study shows nicotine reduces α-synuclein pathology and behavioral deficits in mice induced by human α-synuclein pre-formed fibrils.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

Sinorhizobium meliloti BR-bodies promote fitness during host colonization

This study shows that BR-bodies in Sinorhizobium meliloti enhance mRNA decay efficiency and symbiotic fitness during host colonization.

Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.

Centriole structural integrity defects are a crucial feature of Hydrolethalus Syndrome

This study shows that HYLS1 mutations cause centriole structural defects leading to ciliary dysfunction and developmental issues in mice, mirroring human Hydrolethalus Syndrome.

A Real-time Multi-Subject Three Dimensional Pose Tracking System for Analyzing Social Behaviors of Non-human Primates

This paper introduces MarmoPose, a real-time 3D pose tracking system for non-human primates, enabling analysis of social behaviors and closed-loop experiments in marmosets.

Multiplexed dynamic control of temperature to probe and observe mammalian cells.

The paper introduces thermoPlate, a device for dynamic temperature control in cell culture, and uses it to study temperature-dependent cellular responses like phase separation and stress granule dynamics.

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

Short-chain carboxylates facilitate the counting of yeasts in Sub-high temperature Daqu.

This study investigates the use of short-chain carboxylates to selectively inhibit mold growth in Sub-high temperature Daqu, improving yeast counting efficiency.

Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma

This study identifies how cancer genetics shape the tumor microenvironment in hepatocellular carcinoma, revealing myeloid cell-specific vulnerabilities that can be targeted with GM-CSF inhibition.

ATR promotes mTORC1 activity via de novo cholesterol synthesis

This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.

Engineering Regionally-Activated Drugs for Neuroscience

This paper introduces RAID, a noninvasive method to control specific brain cell types using ultrasound and enzyme-prodrug pairs for sustained neuromodulation.

Transcriptional signatures associated with waterlogging stress responses and aerenchyma formation in barley root tissue

This study identifies transcriptional signatures and candidate genes associated with waterlogging stress responses and aerenchyma formation in barley roots.

Harnessing Landrace Diversity Empowers Wheat Breeding for Climate Resilience

This study uses landrace diversity in wheat to identify genetic resources for climate resilience and improved traits, providing a framework for crop improvement.

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

This study examines the long-term microbial changes in desert soil during ecological restoration, finding shifts in community structure, functional diversity, and biogeochemical cycles over 17 years.

Rapid optogenetic clustering of a cytoplasmic BcLOV4 variant

This paper engineers a BcLOV4 variant, BcLOVclust, that clusters in the cytoplasm without membrane translocation, offering faster kinetics and multiplexing capabilities compared to Cry2.

Longitudinal Awake Imaging of Deep Mouse Brain Microvasculature with Super-resolution Ultrasound Localization Microscopy

This study demonstrates longitudinal awake mouse brain imaging using ultrasound localization microscopy, showing reduced vessel density and flow velocity after anesthesia recovery.

Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease

The paper shows mitochondrial dysfunction in intestinal epithelium leads to microbiota-dependent injury and identifies gene signatures that distinguish active from inactive inflammation in IBD.

Differential Adaptation and Remodeling of the Tumor Microenvironment in Breast Cancer Cells During the Stages of Brain Metastasis

This study compares gene expression between primary and brain metastatic breast cancer cells, identifying differences in pathways and cell states that contribute to metastasis.

Spatiotemporal Control of Genomics and Epigenomics by Ultrasound

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.

Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

This study shows leucine reduces cytokine storm syndrome in mice by promoting M2 macrophage polarization via the mTORC1/LXRα signaling pathway.

Development and Optimisation of in vitro Sonodynamic Therapy for Glioblastoma

The paper develops an automated in vitro sonodynamic therapy system for glioblastoma and demonstrates its efficacy in inducing apoptosis and reducing 3D growth of glioma cells.

Acoustically-Targeted Measurement of Transgene Expression in the Brain

This paper introduces REMIS, a noninvasive method to measure gene expression in the brain using ultrasound and blood tests, and demonstrates its effectiveness in monitoring chemogenetic activity.

A protease and a lipoprotein jointly modulate the conserved ExoR-ExoS-ChvI signaling pathway critical in Sinorhizobium meliloti for symbiosis with legume hosts

This paper identifies two proteins, LppA and JspA, that modulate the ExoR-ExoS-ChvI signaling pathway in S. meliloti, essential for EPS-I production and successful symbiosis with legumes.

Syntheses of Pyrimidine-Modified Seleno-DNAs as Stable Antisense Molecules

This paper synthesizes seleno-modified DNA oligonucleotides and shows they resist nuclease digestion while maintaining RNase H activity.

Duplications of human longevity-associated genes across placental mammals

This study investigates the link between gene duplication and mammalian longevity by analyzing 287 human longevity-associated genes across 37 placental mammals, finding that duplication rates are eight times higher than contraction rates and identifying 43 genes significantly correlated with longevity.

Functional divergences of natural variations of TaNAM-A1 controlling leaf senescence initiation during wheat grain filling

This study identifies TaNAM-A1 as a key gene regulating leaf senescence and grain yield in wheat, showing functional differences among its haplotypes.

Comparative genome microsynteny illuminates the fast evolution of nuclear mitochondrial segments (NUMTs) in mammals

This study investigates NUMT evolution across 45 mammalian genomes using synteny-based methods, revealing their origin patterns and phylogenetic implications.