Author

D. E. MacHugh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Organism:chicken / avian· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. P. McHugo· 2 shared T. J. Hall· 2 shared A. Martinez-Moreno· 1 shared A. Naranjo-Lucena· 1 shared C. Reid· 1 shared C. Scaife· 1 shared D. A. Niedziela· 1 shared D. G. Bradley· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

G. P. McHugo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Unveiling the Role of Endoplasmic Reticulum Stress Pathways in Canine Demodicosis

P. Kelly, G. P. McHugo, C. Scaife, S. Peters, M. L. Stevenson, J. S. McKay, D. E. MacHugh, I. Lara-Saez, R. Breathnach

This study identifies endoplasmic reticulum stress pathways as contributors to canine demodicosis through immunosuppressive mechanisms involving M2 macrophages and TLR2 modulation.

bioRxiv · Aug 11, 2023Immunology

Preferential differential gene expression within the WC1.1+ γδ T cell compartment in cattle naturally infected with Mycobacterium bovis.

S. A. Bhat, M. Elnaggar, T. J. Hall, G. McHugo, C. Reid, D. E. MacHugh, K. G. Meade

This study identifies preferential differential gene expression in WC1.1+ γδ T cells from cattle naturally infected with Mycobacterium bovis, highlighting immune-related functions.

bioRxiv · Jul 21, 2023 · PreprintImmunology

Genome-wide local ancestry and direct evidence for mitonuclear coadaptation in African hybrid cattle populations (Bos taurus/indicus)

J. A. Ward, G. P. McHugo, M. J. Dover, T. J. Hall, S. I. Ng'ang'a, T. S. Sonstegard, D. G. Bradley, L. A. Frantz, M. Salter-Townshend, D. E. MacHugh

The paper uses SNP data to show increased taurine ancestry at mitochondrially-targeted nuclear genes in African cattle hybrids, supporting mitonuclear incompatibility between zebu nuclear and taurine mitochondrial genomes.

bioRxiv · Aug 26, 2021Evolutionary Biology

Timing of transcriptomic peripheral blood mononuclear cell responses of sheep to Fasciola hepatica infection differs from those of cattle, reflecting different disease phenotypes

D. A. Niedziela, A. Naranjo-Lucena, V. Molina-Hernandez, J. A. Browne, A. Martinez-Moreno, J. Perez, D. E. MacHugh, G. Mulcahy

This study compares the transcriptomic responses of sheep and cattle PBMC to Fasciola hepatica infection, finding differences in gene expression and pathway activation that reflect distinct disease outcomes.

bioRxiv · Jun 21, 2021Immunology