Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in Acute Myeloid Leukemia
D. Sanchez Martinez, N. Tirado, S. Mensurado, A. Martinez-Moreno, P. Romecin, F. Gutierrez-Aguera, D. V. Correia, B. Silva-Santos, P. Menendez
This study generates and pre-clinically validates CD123-targeted CAR-DOTs for relapsed/refractory AML, showing robust cytotoxicity and long-term persistence with IL-15 support.
bioRxiv · Mar 15, 2022Immunology