Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy
R. Czapiewski, D. G. Batrakou, J. I. de las Heras, R. N. Carter, A. Sivakumar, M. Sliwinska, C. R. Dixon, S. Webb, G. Lattanzi, N. M. Morton, E. C. Schirmer
This study shows that Tmem120a knockout in mice disrupts fat genome organisation, leading to lipodystrophy and metabolic defects, with similarities to human FPLD2.
bioRxiv · Apr 12, 2021Cell Biology