Author

E. C. Schirmer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:wet-lab / biochemical assay· 2

Frequent Co-Authors

A. Rizzotto· 2 shared C. R. Dixon· 2 shared J. I. de las Heras· 2 shared J. Wildenhain· 2 shared M. Auer· 2 shared N. T. Pham· 2 shared S. Tollis· 2 shared A. A. Jeyaprakash· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

A. Rizzotto

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Estradiol propionate reduction of nuclear size in prostate cancer lines lacking DHRS7suggests DHRS7 absence as a biomarker for the effectiveness of estrogen therapy

A. Rizzotto, S. Tollis, N. T. Pham, Y. Zheng, M. A. Abad, J. Wildenhain, A. A. Jeyaprakash, M. Auer, M. D. Tyers, E. C. Schirmer

The paper shows that DHRS7 loss increases nuclear size in prostate cancer cells and that estradiol propionate reduces nuclear size in DHRS7-lacking cells, suggesting DHRS7 as a biomarker for estrogen therapy effectiveness.

bioRxiv · Sep 18, 2023 · PreprintCancer Biology

Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy

R. Czapiewski, D. G. Batrakou, J. I. de las Heras, R. N. Carter, A. Sivakumar, M. Sliwinska, C. R. Dixon, S. Webb, G. Lattanzi, N. M. Morton, E. C. Schirmer

This study shows that Tmem120a knockout in mice disrupts fat genome organisation, leading to lipodystrophy and metabolic defects, with similarities to human FPLD2.

bioRxiv · Apr 12, 2021Cell Biology

STING Nuclear Partners Contribute to Innate Immune Signalling Responses

C. R. Dixon, P. Malik, J. I. de las Heras, N. Saiz-Ros, F. de Lima Alves, M. Tingey, E. R. Gaunt, C. Richardson, D. Kelly, M. W. Goldberg, G. J. Towers, W. Yang, J. Rappsilber, P. Digard, E. C. Schirmer

The paper identifies nuclear STING partners that contribute to innate immune signaling by interacting with IRF3/7 transcription factors and enhancing antiviral responses.

bioRxiv · Dec 21, 2020Immunology

Chemical-Genetic Interrogation of Nuclear Size Control Reveals Cancer-Specific Effects on Cell Migration and Invasion

A. Rizzotto, S. Tollis, N. T. Pham, J. Wildenhain, N. Zuleger, J. T. Keys, D. Batrakou, J. Culley, S. Zheng, J. Lammerding, N. O. Carragher, V. Brunton, M. Auer, M. Tyers, E. C. Schirmer

The paper identifies compounds that reverse nuclear size changes in cancer cell lines and finds they inhibit cell migration and invasion.

bioRxiv · Jan 10, 2020 · PreprintCancer Biology