N. M. Morton

Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination

This study shows that preneoplastic cells exhibit Warburg metabolism early on, which can be targeted to eliminate them using metabolic inhibitors.

The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

This study investigates how caloric restriction affects adipose tissue and metabolic health, finding that its benefits are sex- and age-dependent in mice and humans.

High-content profiling reveals a unified model of copper ionophore dependent cell death in oesophageal adenocarcinoma

This study identifies a unified mechanism of copper ionophore-induced cell death in oesophageal adenocarcinoma using high-content profiling and omic analyses.

Classical macrophage polarisation is limited by human β-defensin 3 via an autocrine IL-4 dependent process.

This paper shows HBD3 limits macrophage classical activation and promotes alternative activation via IL-4R, enabling a repair-conducive state.

GLUCOCORTICOIDS REGULATE MITOCHONDRIAL FATTY ACID OXIDATION IN FETAL CARDIOMYOCYTES

This study shows that endogenous glucocorticoids promote fatty acid oxidation in fetal cardiomyocytes through gene expression changes, while exogenous glucocorticoids may disrupt this process.

Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy

This study shows that Tmem120a knockout in mice disrupts fat genome organisation, leading to lipodystrophy and metabolic defects, with similarities to human FPLD2.

Adipocyte-specific deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

This study shows that deleting PHD2 in adipocytes maintains BAT activity at thermoneutrality, increases energy expenditure, and identifies serum PHD2 as a biomarker for metabolic disease.

PHOSPHO1, a novel skeletal regulator of insulin resistance and obesity

This study shows that PHOSPHO1 deficiency improves glucose homeostasis and protects against obesity and diabetes without altering osteocalcin levels.

The hepatic compensatory response to elevated systemic sulfide promotes diabetes

This study shows that mice lacking the sulfide oxidation pathway enzyme TST exhibit metabolic abnormalities despite insulin sensitization, highlighting TST's role in hepatic metabolism and potential implications for sulfide-donor therapies.

Nonalcoholic fatty liver disease is associated with decreased hepatocyte mitochondrial respiration but not mitochondrial number

This study shows that NAFLD is linked to reduced mitochondrial respiration but not mitochondrial number or fragmentation in a human stem cell model.

Bone marrow adipose tissue is a unique adipose subtype with distinct roles in systemic glucose homeostasis

This study identifies bone marrow adipose tissue (BMAT) as a distinct adipose subtype with unique metabolic functions in glucose homeostasis.