Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity
T. D. Heden, J. M. Johnson, P. J. Ferrara, H. Eshima, A. R. Verkerke, E. J. Wentzler, P. Siripoksup, T. M. Narowski, C. B. Coleman, C.-T. Lin, T. E. Ryan, P. T. Reidy, L. E. de Castro Bras, C. M. Karner, C. F. Burant, , K. Funai
The paper shows that mitochondrial phospholipids, specifically phosphatidylethanolamine (PE), regulate respiratory capacity in skeletal muscle, with PE deficiency causing respiratory failure and oxidative stress.
bioRxiv · Apr 9, 2019Physiology