K. Funai

Skeletal muscle PGC-1α remodels mitochondrial phospholipidome but does not alter energy efficiency for ATP synthesis

This study shows PGC-1α overexpression in skeletal muscle changes mitochondrial lipid composition but does not improve ATP synthesis efficiency.

Lipid peroxidation does not mediate muscle atrophy induced by PSD deficiency

This study investigates whether lipid peroxidation mediates muscle atrophy caused by PSD deficiency and finds that it does not.

Inhibition of skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity

This study shows that inhibiting the Lands cycle in skeletal muscle reduces lipid hydroperoxide levels, protecting against disuse-induced atrophy and weakness in mice.

Weight loss improves skeletal muscle mitochondrial energy efficiency

This study shows weight loss increases skeletal muscle mitochondrial energy efficiency by altering cardiolipin composition, which reduces energy expenditure and prevents weight regain.

Phosphatidylethanolamine facilitates mitochondrial pyruvate entry to regulate metabolic flexibility

This study identifies phosphatidylethanolamine's role in regulating mitochondrial pyruvate entry, linking it to metabolic flexibility in skeletal muscle.

Mitochondrial Phosphatidylethanolamine Directly Regulates UCP1 to Promote Brown Adipose Thermogenesis

This study shows mitochondrial phosphatidylethanolamine directly regulates UCP1 to control thermogenesis in brown adipose tissue.

m6A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small cell lung cancer

Lipid hydroperoxides promote sarcopenia through carbonyl stress

This study shows lipid hydroperoxides contribute to sarcopenia by causing carbonyl stress, and their neutralization prevents muscle atrophy and weakness.

EFHD1 ablation reduces cardiac mitoflash activation and protects cardiomyocytes from ischemia.

This study shows that EFHD1 deletion reduces mitochondrial Ca2+ overload and ROS production, protecting cardiomyocytes from ischemia-induced injury.

Mitochondrial fatty acid synthesis coordinates mitochondrial oxidative metabolism

This study shows that mitochondrial fatty acid synthesis (mtFAS) regulates electron transport chain (ETC) complexes and skeletal myoblast differentiation, linking fatty acid synthesis to oxidative metabolism.

The Lands cycle modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle

The study identifies LPCAT3 as a key regulator of plasma membrane lipid organization and insulin sensitivity in skeletal muscle, showing its role in modulating lipid metabolism and insulin action.

Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity

The paper shows that mitochondrial phospholipids, specifically phosphatidylethanolamine (PE), regulate respiratory capacity in skeletal muscle, with PE deficiency causing respiratory failure and oxidative stress.

Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

This study identifies mitochondrial dysfunction and reduced fatty acid oxidation as causes of lipid accumulation in myosteatosis using a rat rotator cuff injury model.