Author

P. J. Ferrara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Physiology· 6

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 3 Assay:metabolomics· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

K. Funai· 6 shared J. A. Maschek· 5 shared J. E. Cox· 5 shared J. M. Johnson· 4 shared P. Siripoksup· 4 shared A. R. Verkerke· 3 shared H. Eshima· 3 shared M. J. Drummond· 3 shared

Activity by Year

2018-2023 · peak 2/yr

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10 top collaborators · 44 mutual co-author links

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6 shared papersPhysiology

K. Funai

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6 papers

Recent·Most cited

Inhibition of skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity

J. L. Shahtout, H. Eshima, P. J. Ferrara, J. A. Maschek, J. E. Cox, M. J. Drummond, K. Funai

This study shows that inhibiting the Lands cycle in skeletal muscle reduces lipid hydroperoxide levels, protecting against disuse-induced atrophy and weakness in mice.

bioRxiv · Jul 25, 2023Physiology

Weight loss improves skeletal muscle mitochondrial energy efficiency

P. J. Ferrara, M. J. Lang, J. M. Johnson, S. Watanabe, K. L. McLaughlin, J. A. Maschek, A. R. Verkerke, P. Siripoksup, A. Chaix, J. E. Cox, K. H. Fisher-Wellman, K. Funai

This study shows weight loss increases skeletal muscle mitochondrial energy efficiency by altering cardiolipin composition, which reduces energy expenditure and prevents weight regain.

bioRxiv · Dec 21, 2022 · PreprintPhysiology

Lipid hydroperoxides promote sarcopenia through carbonyl stress

H. Eshima, J. L. Shahtout, P. Siripoksup, M. J. Pearson, Z. S. Mahmassani, P. J. Ferrara, A. W. Lyons, J. A. Maschek, A. D. Peterlin, A. R. P. Verkerke, J. M. Johnson, A. Salcedo, J. J. Petrocelli, E. R. Miranda, E. J. Anderson, , K. Funai

This study shows lipid hydroperoxides contribute to sarcopenia by causing carbonyl stress, and their neutralization prevents muscle atrophy and weakness.

bioRxiv · Dec 17, 2021Physiology

The Lands cycle modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle

P. J. Ferrara, X. Rong, J. A. Maschek, A. R. Verkerke, P. Siripoksup, H. Song, K. C. Krishnan, J. M. Johnson, J. Turk, J. A. Houmard, A. J. Lusis, J. E. Cox, S. R. Shaikh, P. Tontonoz, K. Funai

The study identifies LPCAT3 as a key regulator of plasma membrane lipid organization and insulin sensitivity in skeletal muscle, showing its role in modulating lipid metabolism and insulin action.

bioRxiv · Dec 23, 2019 · PreprintPhysiology

Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity

T. D. Heden, J. M. Johnson, P. J. Ferrara, H. Eshima, A. R. Verkerke, E. J. Wentzler, P. Siripoksup, T. M. Narowski, C. B. Coleman, C.-T. Lin, T. E. Ryan, P. T. Reidy, L. E. de Castro Bras, C. M. Karner, C. F. Burant, , K. Funai

The paper shows that mitochondrial phospholipids, specifically phosphatidylethanolamine (PE), regulate respiratory capacity in skeletal muscle, with PE deficiency causing respiratory failure and oxidative stress.

bioRxiv · Apr 9, 2019Physiology

Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

J. P. Gumucio, A. H. Qasawa, P. J. Ferrara, A. N. Malik, K. Funai, B. McDonagh, C. L. Mendias

This study identifies mitochondrial dysfunction and reduced fatty acid oxidation as causes of lipid accumulation in myosteatosis using a rat rotator cuff injury model.

bioRxiv · Nov 18, 2018Physiology