Soluble signal inhibitory receptor on leukocytes-1 is released from activated neutrophils by proteinase 3 cleavage
H. J. von Richthofen, G. H. A. Westerlaken, D. Gollnast, S. Besteman, E. M. Delemarre, K. Rodenburg, P. Moerer, D. A. C. Stapels, A. K. Andiappan, O. Rotzschke, S. Nierkens, H. L. Leavis, L. J. Bont, S. H. M. Rooijakkers, L. Meyaard
The paper shows that activated neutrophils release soluble SIRL-1 via proteinase 3 cleavage, and that sSIRL-1 is present in vivo in RSV and COVID-19 patients.
bioRxiv · Mar 3, 2022Immunology