Author

O. Rotzschke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. Lee· 3 shared A. K. Andiappan· 2 shared B. E. Young· 2 shared D. C. Lye· 2 shared G. Carissimo· 2 shared K. J. Puan· 2 shared L. Renia· 2 shared N. K.-W. Yeo· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

B. Lee

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Semaphorin3F reduces vascular endothelial and smooth muscle cell PI3K activation and decreases neointimal plaque formation

C. Rattanasopa, D. Castano Mayan, C. Su, A. J. Farrugia, M. Corliano, P. Nilcham, C. Pang, M. Hota, S. M. Koh, W. W. Lee, D. M. Cibi, A. Aiba, M. K. Singh, S. C. Wong, O. Rotzschke, , R. R. Singaraja

This study shows that Semaphorin3F reduces PI3K activation in vascular endothelial and smooth muscle cells, leading to decreased neointimal plaque formation and increased plaque stability.

bioRxiv · Mar 22, 2022 · PreprintPhysiology

Soluble signal inhibitory receptor on leukocytes-1 is released from activated neutrophils by proteinase 3 cleavage

H. J. von Richthofen, G. H. A. Westerlaken, D. Gollnast, S. Besteman, E. M. Delemarre, K. Rodenburg, P. Moerer, D. A. C. Stapels, A. K. Andiappan, O. Rotzschke, S. Nierkens, H. L. Leavis, L. J. Bont, S. H. M. Rooijakkers, L. Meyaard

The paper shows that activated neutrophils release soluble SIRL-1 via proteinase 3 cleavage, and that sSIRL-1 is present in vivo in RSV and COVID-19 patients.

bioRxiv · Mar 3, 2022Immunology

Preserved T cell reactivity to the SARS-CoV-2 Omicron variant indicates continued protection in vaccinated individuals.

L. De Marco, S. D'Orso, M. Pirronello, A. Verdiani, A. Termine, C. Fabrizio, A. Capone, A. Sabatini, G. Guerrera, R. Placido, M. Sambucci, D. F. Angelini, F. Giannessi, M. Picozza, C. Caltagirone, , G. Borsellino

The study assesses T cell reactivity to the SARS-CoV-2 Omicron variant in vaccinated individuals and finds reduced recognition of mutated Spike regions but preserved overall reactivity.

bioRxiv · Dec 30, 2021Immunology

Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response

J. Lim, G. Carissimo, Y.-H. Chan, S.-W. Fong, W. W. Lee, S.-Y. Tan, D. C. Lye, B. E. Young, L. Renia, L. Fong-Poh NG, O. Rotzschke, K. J. Puan, L. W. Wang, K. W. W. Teng, C. Y. Loh, , B. Lee

The paper identifies immune signatures associated with COVID-19 severity and temporality, revealing distinct patterns and providing tools for data analysis.

bioRxiv · Feb 10, 2021 · PreprintImmunology

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19

G. Carissimo, W. Xu, I. Kwok, M. Y. Abdad, Y. H. Chan, S. W. Fong, K. J. Puan, C. Y. P. Lee, N. K.-W. Yeo, S. N. Amrun, R. S.-L. Chee, W. How, S. Chan, E. B. Fan, A. Andiappan, , L. F. Ng

The paper identifies an immature neutrophil-to-VD2 T-cell ratio as a prognostic marker for severe COVID-19 using flow cytometry data.

bioRxiv · Jun 11, 2020Immunology

Histone acetylome-wide association study of tuberculosis

R. C. H. del Rosario, J. Poschmann, P. Kumar, C. Y. Cheng, S. T. Ong, H. S. Hajan, D. Kumar, M. Marzuki, X. Lu, A. Lee, Y. Tang, C. B. E. Chee, C. Lim, B. Lee, J. Lum, , S. Prabhakar

This study conducts a histone acetylome-wide association study (HAWAS) of tuberculosis, identifying differentially acetylated loci and their association with immune phenotypes.

bioRxiv · May 21, 2019 · PreprintImmunology