Author

D. A. C. Stapels

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:E. coli· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

S. H. M. Rooijakkers· 2 shared A. K. Andiappan· 1 shared B. W. Bardoel· 1 shared C. J. C. de Haas· 1 shared D. A. C. Heesterbeek· 1 shared D. Gollnast· 1 shared D. J. Doorduijn· 1 shared E. M. Delemarre· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

S. H. M. Rooijakkers

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Soluble signal inhibitory receptor on leukocytes-1 is released from activated neutrophils by proteinase 3 cleavage

H. J. von Richthofen, G. H. A. Westerlaken, D. Gollnast, S. Besteman, E. M. Delemarre, K. Rodenburg, P. Moerer, D. A. C. Stapels, A. K. Andiappan, O. Rotzschke, S. Nierkens, H. L. Leavis, L. J. Bont, S. H. M. Rooijakkers, L. Meyaard

The paper shows that activated neutrophils release soluble SIRL-1 via proteinase 3 cleavage, and that sSIRL-1 is present in vivo in RSV and COVID-19 patients.

bioRxiv · Mar 3, 2022Immunology

Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores

D. J. Doorduijn, D. A. C. Heesterbeek, M. Ruyken, C. J. C. de Haas, D. A. C. Stapels, P. C. Aerts, S. H. M. Rooijakkers, B. W. Bardoel

This study shows that C9 polymerization enhances MAC pore-mediated bacterial killing and is impaired in complement-resistant strains.

bioRxiv · May 12, 2021Microbiology