Author

D. Gurvic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:E. coli· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

U. Zachariae· 2 shared A. A. Eze· 1 shared A. Alghamdi· 1 shared A. Dimitriou· 1 shared A. Kumar· 1 shared C. Dardonville· 1 shared C. E. Okpara· 1 shared C. M. Woodley· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

U. Zachariae

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Author profile →

2 papers

Recent·Most cited

Multidrug Efflux in Gram-Negative Bacteria: Rationally Modifying Compounds to Avoid Efflux Pumps

D. Gurvic, U. Zachariae

The paper analyzes over 73,000 compounds in E. coli strains to identify chemical features that help evade efflux pumps, showing efflux's major role in drug bioactivity.

bioRxiv · Jul 13, 2023 · PreprintPharmacology & Toxicology

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

A. Alghamdi, J. C. Munday, G. D. Campagnaro, D. Gurvic, F. Svensson, C. E. Okpara, A. Kumar, M. E. Martin Abril, P. Mili?, L. Watson, D. Paape, L. Settimo, A. Dimitriou, J. Wielinska, G. Smart, , H. P. De Koning

The paper identifies mutations in TbAQP2 that enable pentamidine permeation, showing how specific structural changes in the aquaporin pore allow drug entry in Trypanosoma brucei.

bioRxiv · Mar 8, 2020Biochemistry