Author

A. Dimitriou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. A. Eze· 1 shared A. A. Tzika· 1 shared A. Alghamdi· 1 shared A. Apostolou· 1 shared A. Banerjee· 1 shared A. Chakraborty· 1 shared A. J. Murphy· 1 shared A. Kumar· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperBiochemistry

A. A. Eze

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Skeletal Muscle Mitochondrial Dysfunction Mediated by Pseudomonas aeruginosa Quorum Sensing Transcription Factor MvfR: Reversing Effects with Anti-MvfR and Mitochondrial-Targeted Compounds

L. Rahme, S. Aggarwal, V. K. Singh, A. Chakraborty, S. Cha, A. Dimitriou, C. M. de Crescenzo, O. Izikson, L. Yu, R. Plebani, A. A. Tzika

This study investigates how Pseudomonas aeruginosa's MvfR quorum sensing transcription factor disrupts mitochondrial function in skeletal muscle and shows that inhibiting MvfR or using mitochondrial-targeted compounds can reverse these effects.

bioRxiv · May 3, 2024 · PreprintMicrobiology

A Micro-engineered Human Colon Intestine-Chip Platform to Study Leaky Barrier

A. Apostolou, R. Panchakshari, A. Banerjee, D. V. Manatakis, M. D. Paraskevopoulou, R. Luc, G. Abu Ali, A. Dimitriou, C. Lucchesi, G. Kulkarni, T. I. Maulana, B. Bleck, E. S. Manolakos, G. A. Hamilton, C. Giallourakis, K. Karalis

This paper introduces a Colon Intestine-Chip platform to study leaky gut by combining organoids and Organ-on-Chip technologies, showing its response to inflammatory cytokines and IL-22.

bioRxiv · Aug 28, 2020 · PreprintBioengineering

The finger 2 tip loop of Activin A is required for the formation of its non-signaling complex with ACVR1 and type II Bone Morphogenetic Protein receptors

S. Aykul, R. A. Corpina, E. J. Goebel, C. J. Cunanan, A. Dimitriou, H. Kim, Q. Zhang, A. Rafique, R. Leidich, X. Wang, J. McClain, J. Jimenez, K. C. Nannuru, N. J. Rothman, J. B. Lees-Shepard, , V. Idone

The paper shows that the non-signaling complex formed by Activin A and ACVR1 reduces disease severity in FOP by tempering heterotopic ossification.

bioRxiv · May 28, 2020 · PreprintCell Biology

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

A. Alghamdi, J. C. Munday, G. D. Campagnaro, D. Gurvic, F. Svensson, C. E. Okpara, A. Kumar, M. E. Martin Abril, P. Mili?, L. Watson, D. Paape, L. Settimo, A. Dimitriou, J. Wielinska, G. Smart, , H. P. De Koning

The paper identifies mutations in TbAQP2 that enable pentamidine permeation, showing how specific structural changes in the aquaporin pore allow drug entry in Trypanosoma brucei.

bioRxiv · Mar 8, 2020Biochemistry