Author

D. Paape

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. A. Eze· 1 shared A. Alghamdi· 1 shared A. Dimitriou· 1 shared A. J. M. Wollman· 1 shared A. Kumar· 1 shared C. Bower-Lepts· 1 shared C. Dardonville· 1 shared C. E. Okpara· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. A. Eze

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Author profile →

2 papers

Recent·Most cited

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

A. Alghamdi, J. C. Munday, G. D. Campagnaro, D. Gurvic, F. Svensson, C. E. Okpara, A. Kumar, M. E. Martin Abril, P. Mili?, L. Watson, D. Paape, L. Settimo, A. Dimitriou, J. Wielinska, G. Smart, , H. P. De Koning

The paper identifies mutations in TbAQP2 that enable pentamidine permeation, showing how specific structural changes in the aquaporin pore allow drug entry in Trypanosoma brucei.

bioRxiv · Mar 8, 2020Biochemistry

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

M. Saldivia, S. P. S. Rao, E. Fang, E. Myburgh, E. Brown, A. J. M. Wollman, R. Ritchie, S. B. Lakhsminarayana, Y. L. Chen, D. Patra, H. X. Koh, S. Williams, F. Supek, D. Paape, C. Bower-Lepts, , J. C. Mottram

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.

bioRxiv · Apr 24, 2019Microbiology