Author

H. P. De Koning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J. C. Munday· 2 shared A. A. Eze· 1 shared A. Alghamdi· 1 shared A. Brennand· 1 shared A. Dimitriou· 1 shared A. Kumar· 1 shared A. L. Goerner· 1 shared B. Martorelli di Genova· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

J. C. Munday

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Author profile →

3 papers

Recent·Most cited

Pyrimidine salvage in Toxoplasma gondii as a target for new treatment

H. A. A. Elati, A. L. Goerner, B. Martorelli di Genova, L. Sheiner, H. P. De Koning

This paper identifies TgUUT1 as a key pyrimidine salvage transporter in Toxoplasma gondii and demonstrates that 5F-uracil derivatives are potent antiparasitic agents with efficacy comparable to sulfadiazine.

bioRxiv · Nov 1, 2023 · PreprintMicrobiology

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in T. brucei

S. Bachmaier, M. K. Gould, E. Polatoglou, R. Omelianczyk, A. Brennand, M. A. Aloraini, J. C. Munday, D. Horn, M. Boshart, H. P. De Koning

The paper identifies ten cAMP Response Proteins (CARPs) in T. brucei, localized to the flagellum, involved in cAMP pathways, with two shown to bind cAMP.

bioRxiv · Mar 14, 2023 · PreprintMicrobiology

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

A. Alghamdi, J. C. Munday, G. D. Campagnaro, D. Gurvic, F. Svensson, C. E. Okpara, A. Kumar, M. E. Martin Abril, P. Mili?, L. Watson, D. Paape, L. Settimo, A. Dimitriou, J. Wielinska, G. Smart, , H. P. De Koning

The paper identifies mutations in TbAQP2 that enable pentamidine permeation, showing how specific structural changes in the aquaporin pore allow drug entry in Trypanosoma brucei.

bioRxiv · Mar 8, 2020Biochemistry