N. Lee

PicoCam: High-resolution 3D imaging of live animals and preserved specimens

The paper introduces PicoCam, a 3D imaging system for live animals and preserved specimens, and demonstrates its use in measuring hummingbird bills with high precision.

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1

This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.

An epigenetically distinct HSC subset supports thymic reconstitution

This study identifies an epigenetically distinct HSC subset, Kitlo, that supports better thymic and T-cell reconstitution in mice and humans.

Florigen-producing cells express FPF1-LIKE PROTEIN 1 that accelerates flowering and stem growth in long days with sunlight red/far-red ratio in Arabidopsis

The paper identifies FLP1 as a gene expressed in FT-producing cells in Arabidopsis that promotes flowering and stem growth under long-day conditions.

Resource competition affects the developmental outcome of the acoustic parasitoid fly Ormia ochracea

This study shows that resource competition negatively affects the developmental outcomes of Ormia ochracea larvae when using Acheta domesticus as a host, with smaller pupae and lower eclosion success under competitive conditions.

Streptococcus pneumoniae infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases

This study shows that pneumolysin from Streptococcus pneumoniae causes internalization of GPI-anchored proteins in lung epithelial cells via Rho GTPase activation, reducing cell death and membrane damage.

Multi-Omics after O-GlcNAc Alteration Identifies Cellular Processes Working Synergistically to Promote Aneuploidy

The paper uses multi-omics analysis to show OGT regulates aneuploidy by fine-tuning multiple cellular pathways through O-GlcNAcylation.

The host GTPase Dynamin 2 modulates apical junction structure to control cell-to-cell spread of Listeria monocytogenes

This study shows that Dynamin 2 and Tuba modulate apical junction structure to control cell-to-cell spread of Listeria monocytogenes by regulating cortical tension.

Selenium reduction of ubiquinone via SQOR suppresses ferroptosis

The paper shows selenium reduces ubiquinone to ubiquinol via SQOR, protecting against ferroptosis independently of selenoprotein production.

Effects of Ambient Temperature on the Recognition and Preferences for Host Song Pulse-rate by the Acoustic Parasitoid Fly Ormia ochracea

This study examines how ambient temperature affects the song pulse rate preferences of the parasitoid fly Ormia ochracea in response to cricket songs.

Age-related epithelial defects limit thymic function and regeneration

The paper identifies age-related thymic epithelial cell states that impair thymic regeneration and immune function through spatial and single-cell transcriptomics.

Regulation of Liver Regeneration by hepatocyte O-GlcNAcylation in mice

This study shows that O-GlcNAcylation in hepatocytes is essential for proper liver regeneration, with its loss leading to uncontrolled proliferation and tumor formation.

The Role of Low Molecular Weight Fungal Metabolites in Grapevine Trunk Disease Pathogenesis: Eutypa Dieback and Esca

This paper investigates how low molecular weight metabolites from fungal pathogens contribute to grapevine trunk disease pathogenesis through non-enzymatic redox reactions and chelator-mediated Fenton chemistry.

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

This study identifies H522 cells as ACE2-negative human cells permissive to SARS-CoV-2 infection, revealing alternative receptor usage and host response mechanisms.

Chemotherapy coupled to macrophage inhibition leads to enhanced T and B cell infiltration and durable triple negative breast cancer regression

The impact of Spike mutations on SARS-CoV-2 neutralization

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

Asymmetric chromatin capture and nuclear envelopes separate chromosomes in fused cells during mitosis

The paper investigates how hybrid Drosophila cells separate chromosomes of different origin during mitosis using asymmetric chromatin capture and nuclear envelopes.

Human spinal cord organoids exhibiting neural tube morphogenesis for a quantifiable drug screening system of neural tube defects

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

The translational landscape of SARS-CoV-2 and infected cells

This study uses ribosome profiling to analyze SARS-CoV-2 and host mRNA translation in infected cells, finding that viral mRNAs are not more efficiently translated than host mRNAs and highlighting unique translational strategies.

Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

Lung-to-ear sound transmission does not improve directional hearing in green treefrogs (Hyla cinerea)

This study tests whether lung-to-ear sound transmission improves directional hearing in green treefrogs, finding no significant effect on binaural directionality.

Lungs contribute to solving the frog's cocktail party problem by enhancing the spectral contrast of conspecific vocal signals

The paper shows that frog lungs enhance spectral contrast of vocal signals by reducing tympanic sensitivity at overlapping frequencies, helping frogs communicate in noisy environments.

A meta-analysis of the inhibin network reveals prognostic value in multiple solid tumors

This study performs a meta-analysis of the inhibin network to assess its prognostic value in multiple solid tumors, identifying key dependencies and therapeutic implications.

Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis

This study identifies COUP-TFII as a driver of myofibroblast metabolic shift to aerobic glycolysis, promoting fibrosis in multiple organs.

Building customizable auto-luminescent luciferase-based reporters in plants

This paper develops a fungal bioluminescence pathway in plants to create auto-luminescent reporters for gene expression and hormone flux studies without external substrate.

Reproducibility test of radiomics using network analysis and Wasserstein K-means algorithm

This paper develops a network-based method to identify reproducible radiomic features across different imaging settings and validates it using phantom and external datasets.

Altered Nucleoprotein Binding to Influenza Virus RNA Impacts Packaging Efficiency and Replication

This study shows that changes in one influenza virus RNA segment's nucleotide sequence can alter NP binding across the entire genome, impacting replication efficiency.

Palbociclib and fulvestrant act in synergy to modulate central carbon metabolism in breast cancer cells

This study investigates how palbociclib and fulvestrant affect metabolic pathways in breast cancer cells, finding synergistic effects when combined.

Crowdsourcing Image Analysis for Plant Phenomics to Generate Ground Truth Data for Machine Learning

This paper evaluates crowdsourcing for generating high-quality ground truth data for machine learning in plant phenomics, finding that Amazon MTurk workers match expert performance.

Spatiotemporally controlled Myosin relocalization and internal pressure cause biased cortical extension to generate sibling cell size asymmetry

The paper investigates the biophysical forces driving asymmetric cell division in Drosophila neural stem cells, showing hydrostatic pressure and Myosin relocalization contribute to sibling cell size asymmetry.