Mutational switch-backs can accelerate evolution of Francisella to a combination of ciprofloxacin and doxycycline
H. H. Mehta, D. Ibarra, C. J. Marx, C. R. Miller, Y. Shamoo
This paper shows that using non-interacting drugs ciprofloxacin and doxycycline together can lead to faster evolution of resistance in Francisella compared to using them sequentially.
bioRxiv · Dec 3, 2021Evolutionary Biology