C. R. Miller

Genomic and ecological factors shaping specialism and generalism across an entire subphylum

The paper analyzes genomic, metabolic, and ecological data from nearly all Saccharomycotina yeast species to show that intrinsic genetic factors, not trade-offs or extrinsic factors, drive variation in niche breadth.

Assessment of treatment-specific tethering survival bias for the juvenile blue crab Callinectes sapidus in a simulated salt marsh

The paper tests if tethering juvenile blue crabs in simulated salt marsh habitats introduces treatment-specific survival bias, finding no such bias across varying shoot densities.

PVT1, a YAP1 dependent stress responsive lncRNA drives ovarian cancer metastasis and chemoresistance

This study identifies PVT1, a YAP1-dependent stress-responsive lncRNA that promotes ovarian cancer metastasis and chemoresistance, suggesting it as a therapeutic target.

Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer

This study identifies Sox2 as a key node regulated by opposing TGF-β superfamily signals, impacting anoikis resistance and metastasis in ovarian cancer.

Mutational switch-backs can accelerate evolution of Francisella to a combination of ciprofloxacin and doxycycline

This paper shows that using non-interacting drugs ciprofloxacin and doxycycline together can lead to faster evolution of resistance in Francisella compared to using them sequentially.

Global composition of the bacteriophage community in honeybees

The paper sequences and compares bacteriophage communities in honeybees from three global locations, finding many novel phages and shared ones, suggesting specialization in the bee gut.

SARS-CoV-2 Viral Replication in a High Throughput Human Primary Epithelial Airway Organ Model

This paper demonstrates SARS-CoV-2 infection and replication in a human primary airway epithelial organ-on-chip model, providing a new platform for disease modeling and drug screening.

Rhinovirus reduces the severity of subsequent respiratory viral infections by interferon-dependent and -independent mechanisms

This study shows that rhinovirus infection reduces severity of subsequent respiratory viral infections through both IFN-dependent and -independent mechanisms in mice.

High-Throughput Human Primary Cell-Based Airway Model for Evaluating Influenza, Coronavirus, or other Respiratory Viruses in vitro

This paper introduces a human primary airway epithelial cell-based model for evaluating influenza and coronavirus infections in vitro, demonstrating its ability to assess viral infection kinetics and therapeutic efficacy.

Comparative molecular life history of spontaneous canine and human gliomas

This study compares molecular profiles of canine and human gliomas to identify conserved mutational processes and similarities in tumor development.

Selecting among three basic fitness landscape models: additive, multiplicative and stickbreaking

The paper develops Bayesian methods to select among three fitness landscape models using mutation combinatorial networks and applies them to published datasets.

Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses

The paper compares gene expression responses of murine lung epithelial cells to three respiratory viruses, identifying shared and virus-specific transcriptional signatures.