Author

H. H. Mehta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:E. coli· 3 Assay:proteomics· 3 Organism:bacteria (other)· 2 Assay:whole-genome sequencing· 2 Organism:C. elegans· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Y. Shamoo· 5 shared A. G. Prater· 3 shared C. A. Arias· 3 shared T. T. Tran· 3 shared W. R. Miller· 3 shared A. Supandy· 2 shared K. Beabout· 2 shared A. Alcala· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersEvolutionary Biology

Y. Shamoo

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Author profile →

6 papers

Recent·Most cited

Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging.

N. Dutta, J. A. Gerke, S. F. Ordon, J. D. Morris, A. Hruby, T. C. Torres, S. Shemtov, J. G. Clark, M. C. Chang, H. Shaghasi, M. N. Ray, M. Averbukh, S. Hoang, M. Oorloff, A. Alcala, , R. Higuchi-Sanabria

This study investigates the effects of marine sponge-derived mycothiazole and its acetylated derivative on mitochondrial function and aging using in vitro and in vivo models.

bioRxiv · Nov 27, 2023Cell Biology

Evolution of Enterococcus faecium to A Combination of Daptomycin and Fosfomycin Reveals Distinct and Diverse Adaptive Strategies

A. Supandy, H. H. Mehta, T. T. Tran, W. R. Miller, R. Zhang, L. Xu, C. A. Arias, Y. Shamoo

This study investigates how Enterococcus faecium develops resistance to a combination of daptomycin and fosfomycin, finding that resistance mechanisms are largely independent and that fosfomycin resistance involves changes in phosphoenolpyruvate flux.

bioRxiv · Dec 20, 2021 · PreprintEvolutionary Biology

Mutational switch-backs can accelerate evolution of Francisella to a combination of ciprofloxacin and doxycycline

H. H. Mehta, D. Ibarra, C. J. Marx, C. R. Miller, Y. Shamoo

This paper shows that using non-interacting drugs ciprofloxacin and doxycycline together can lead to faster evolution of resistance in Francisella compared to using them sequentially.

bioRxiv · Dec 3, 2021Evolutionary Biology

Daptomycin resistance in Enterococcus faecium can be delayed by disruption of the LiaFSR stress response pathway

A. G. Prater, H. H. Mehta, K. Beabout, A. Supandy, W. R. Miller, T. T. Tran, C. A. Arias, Y. Shamoo

This study shows that disrupting the LiaFSR pathway in Enterococcus faecium delays daptomycin resistance development, suggesting potential for combinatorial therapy with a LiaFSR inhibitor.

bioRxiv · Jun 23, 2020Microbiology

Environment Shapes the Accessible Daptomycin Resistance Mechanisms in Enterococcus faecium

A. G. Prater, H. H. Mehta, A. J. Kosgei, W. R. Miller, T. T. Tran, C. A. Arias, Y. Shamoo

This study shows how different environments shape daptomycin resistance mechanisms in Enterococcus faecium through distinct evolutionary pathways.

bioRxiv · Apr 12, 2019Evolutionary Biology

The essential role of hypermutation in rapid adaptation to antibiotic stress

H. H. Mehta, A. G. Prater, K. Beabout, R. Elworth, M. Karavis, H. S. Gibbons, Y. Shamoo

This study examines hypermutation's role in Pseudomonas aeruginosa adaptation to colistin, identifying adaptive mutations and highlighting the risk of re-infection from susceptible cells.

bioRxiv · Sep 20, 2018Evolutionary Biology