Author

D. J. Christini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:simulation· 1

Frequent Co-Authors

A. P. Clark· 2 shared S. Wei· 2 shared T. Krogh-Madsen· 2 shared C. L. Lei· 1 shared G. R. Mirams· 1 shared M. Clerx· 1 shared T. de Boer· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersPhysiology

A. P. Clark

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2 papers

Recent·Most cited

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

A. P. Clark, M. Clerx, S. Wei, C. L. Lei, T. de Boer, G. R. Mirams, D. J. Christini, T. Krogh-Madsen

This paper shows seal-leak current affects iPSC-CM action potential morphology even with high seal resistance, and suggests ways to improve data interpretation and modeling.

bioRxiv · Oct 13, 2022Physiology

A model-guided pipeline for drug cardiotoxicity screening with human stem-cell derived cardiomyocytes

A. P. Clark, S. Wei, T. Krogh-Madsen, D. J. Christini

This study develops an in vitro-in silico pipeline using iPSC-CMs to screen for drug cardiotoxicity by evaluating proarrhythmia risk and ion channel block mechanisms.

bioRxiv · Sep 10, 2021 · PreprintBioengineering