Author

A. P. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

T. Krogh-Madsen· 4 shared S. Wei· 3 shared D. Christini· 2 shared D. J. Christini· 2 shared A. Paap· 1 shared C. L. Lei· 1 shared G. R. Mirams· 1 shared J. J. Saucerman· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersPhysiology

T. Krogh-Madsen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Logic-based modeling of biological networks with Netflux

A. P. Clark, M. Chowkwale, A. Paap, S. Dang, J. J. Saucerman

The paper introduces Netflux, a user-friendly tool for simulating biological networks without programming, and provides a tutorial on its use for modeling and perturbation analysis.

PLOS Computational Biology · Apr 4, 2025Peer-reviewedBioengineering

Optimization of a Cardiomyocyte Model Illuminates Role of Increased INaL in Repolarization Reserve

K. E. Fullerton, A. P. Clark, T. Krogh-Madsen, D. Christini

This paper optimizes a cardiomyocyte model using a genetic algorithm to enhance repolarization reserve, revealing an unexpected role of increased late sodium current in maintaining action potential stability.

bioRxiv · Aug 31, 2023 · PreprintPhysiology

Rapid ionic current phenotyping (RICP) identifies mechanistic underpinnings of iPSC-CM AP heterogeneity

A. P. Clark, S. Wei, K. Fullerton, T. Krogh-Madsen, D. Christini

This study introduces RICP to quantify ionic current heterogeneity in iPSC-CMs and identifies key currents determining action potential variability.

bioRxiv · Aug 16, 2023 · PreprintBioengineering

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

A. P. Clark, M. Clerx, S. Wei, C. L. Lei, T. de Boer, G. R. Mirams, D. J. Christini, T. Krogh-Madsen

This paper shows seal-leak current affects iPSC-CM action potential morphology even with high seal resistance, and suggests ways to improve data interpretation and modeling.

bioRxiv · Oct 13, 2022Physiology

A model-guided pipeline for drug cardiotoxicity screening with human stem-cell derived cardiomyocytes

A. P. Clark, S. Wei, T. Krogh-Madsen, D. J. Christini

This study develops an in vitro-in silico pipeline using iPSC-CMs to screen for drug cardiotoxicity by evaluating proarrhythmia risk and ion channel block mechanisms.

bioRxiv · Sep 10, 2021 · PreprintBioengineering