Author

D. J. Manstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. N. Greve· 2 shared A. Marquardt· 1 shared C. Thiel· 1 shared J. R. Sellers· 1 shared K. Chinthalapudi· 1 shared M. H. Taft· 1 shared M. Preller· 1 shared N. Di Dinato· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

J. N. Greve

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Author profile →

4 papers

Recent·Most cited

Baraitser-Winter Syndrome Hotspot Mutation R196H in Cytoskeletal β-actin Reduces F-actin Stability and Perturbs Interaction with the Arp2/3 Complex

J. N. Greve, D. J. Manstein

This paper investigates the effect of the R196H mutation in β-actin on F-actin stability and its interaction with the Arp2/3 complex, linking these changes to BWCFF pathogenesis.

bioRxiv · Mar 20, 2024 · PreprintBiochemistry

The non-muscle actinopathy-associated mutation E334Q in cytoskeletal gamma-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins

J. N. Greve, A. Marquardt, R. Heiringhoff, T. Reindl, C. Thiel, N. Di Dinato, M. H. Taft, D. J. Manstein

This study characterizes the mutation E334Q in gamma-actin, showing it affects interactions with myosin and ADF/cofilin proteins, potentially contributing to non-muscle actinopathy.

bioRxiv · Sep 10, 2023 · PreprintBiochemistry

Enhanced super-resolution microscopy by combined Airyscan and Quantum-Dot-Triexciton Imaging

S. Hennig, D. J. Manstein

This paper combines Quantum-Dot-Triexciton Imaging with Airyscan to achieve a 3-fold improvement in resolution over standard confocal microscopes.

bioRxiv · May 7, 2020Biophysics

Mechanistic Insights Into The Active Site And Allosteric Communication Pathways In Human Nonmuscle Myosin-2C

K. Chinthalapudi, S. M. Heissler, M. Preller, J. R. Sellers, D. J. Manstein

This study presents a crystal structure of human nonmuscle myosin-2C and identifies an allosteric communication pathway that affects nucleotide binding and release kinetics.

bioRxiv · May 17, 2017Biochemistry