Author

D. Kale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

B. Bruegger· 2 shared P. Phapale· 2 shared A. Palmer· 1 shared B. Brugger· 1 shared C. Luechtenborg· 1 shared C. Thiel· 1 shared D. Avci· 1 shared F. Kikul· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

B. Bruegger

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rv0687 a Putative Short-Chain Dehydrogenase is indispensable for pathogenesis of Mycobacterium tuberculosis.

G. Bhargavi, M. K. Mallakuntla, D. Kale, S. Tiwari

This study shows that Rv0687, a short-chain dehydrogenase in Mycobacterium tuberculosis, is essential for bacterial survival under stress and in host models, reducing pathogenicity and increasing host survival.

bioRxiv · Dec 12, 2023 · PreprintMicrobiology

Simple, rapid, and sensitive quantification of dolichyl phosphates using phosphate methylation and reverse-phase liquid chromatography-high resolution mass spectrometry

D. Kale, F. Kikul, P. Phapale, L. Beedgen, C. Thiel, B. Bruegger

This paper introduces a method to quantify dolichyl phosphates using phosphate methylation and RPLC-MS, applied to yeast, HeLa cells, and fibroblasts from CDG patients and controls.

bioRxiv · Sep 14, 2022 · PreprintBiochemistry

Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme SQS

D. Avci, R. Heidasch, M. Costa, C. Luechtenborg, D. Kale, B. Bruegger, M. K. Lemberg

The paper shows that SPP cleaves SQS at high cholesterol levels, targeting it for degradation via TRC8, thereby regulating mevalonate pathway abundance.

bioRxiv · Jul 19, 2021 · PreprintCell Biology

Public LC-Orbitrap-MS/MS Spectral Library for Metabolite Identification

P. Phapale, A. Palmer, R. M. Gathungu, D. Kale, B. Brugger, T. Alexandrov

The paper constructs and shares an open LC-MS/MS spectral library with over 1600 fragmentation spectra for metabolite identification.

bioRxiv · Nov 21, 2020Biochemistry